Sarah Saleh AlqahtaniUniversité de Picardie Jules Verne, France
Title: The regenerative effect of intra-articular injection of autologous fat micro-graft in treatment of chronic knee osteoarthritis
Osteoarthritis (OA), one of the RMDs, is a degenerative condition that principally involves the joint’s cartilage, leading to its progressive destruction. OA ranks among the ten most disabling conditions in developed countries. The global prevalence of symptomatic OA is estimated as 9.6% in males and 18.0% in females over 60 years of age. As the incidence and prevalence of OA increase with age, the extending life expectancy results in a growing number of people afflicted with OA, with a proportional risk of disability. Knee pain represents more than 80% of the total burden of OA. The treatment of knee OA may use conservative measures including medications, physiotherapy, local injections. After exhausting all previous treatments; a surgical approach is considered. One of the surgical procedures proposed is autologous intra-articular fat micrograft.
Adipose tissue -composed of mature adipocytes, adipocyte derived stem cell (ACS), cytokines, growth factors and other cell types- demonstrate promising clinical application in regenerative therapy for common bone and joint diseases.
Mesenchymal stem cells (MSC) are multipotent adult stem cells obtained from different sources like bone marrow (BM), adipose tissue, umbilical cord, placenta, or synovial membrane. Adipose stem cells were first identified as stem cells in 2001, and are capable to differentiate into cartilage, bone and adipose cells. They represent many advantages compared to other sources of the MSCs, in which they are abundant in the adipose tissue, easier to get compared to BM, and they have strong immunosuppressive capacities.