Shayan AmiriIran University of Medical Sciences, Iran
Title: Moderately elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) in patients with no clinical signs or symptoms of infection is not a contraindication for total knee arthroplasty: A retrospective cohort study
It is unclear whether patients with elevated preoperative levels of erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) are more prone to periprosthetic joint infection (PJI) after total knee arthroplasty (TKA). The authors aimed to determine how preoperative moderate elevation of ESR or CRP in patients without clinical signs or symptoms of infection is associated with the risk of PJI after TKA surgery.In a prospective study, 315 patients who were elected for unilateral TKA were included, including 237 patients with preoperative normal ESR and CRP, 46 patients with moderate preoperative elevation of ESR (less than 50 mm/hr), and 32 patients with moderate preoperative elevation of CRP (less than 24 mg/dL). Patients with both ESR and CRP elevation were not included in the study. primary TKA was done using a standard medial parapatellar approach under general anesthesia. Overall rate of infection was 0.3% (1 in 320 patients) at a mean follow-up period of 19 ± 5.3 mo. This infection occurred in a patient with normal preoperative ESR and CRP (1 in 237 patients, 0.4%). No infection occurred in 78 patients in either the ESRelevated or the CRP-elevated group. Accordingly, the rate of infection was not significantly different between the two groups (P = 0.83) Moderate preoperative elevations of ESR or CRP do not increase the rate of periprosthetic joint infection in patients undergoing total knee arthroplasty.
Shayan Amiri is in the last year of orthopaedic surgery residency in Iran University of Medical Sceinces. He has completed his MD in Shahid Beheshti University of Medical Sciences in 2017. He was chosen as the best researcher of the Iran University in 2021. He can speak English and French fluently. He has published about 10 research relevant to orthopaedic surgery in the past 2 years and also a book about orthopaedics tumors in nova publication.