Jae-sung AhnChungnam National University College of Medicine, South Korea
Title: Efficacy of Bone Graft Material for Spinal Fusion in a Rabbit Model
Spinal fusion is performed to correct spinal instability caused by degenerative changes, trauma, or tumor. In the United States, especially in the past ten years due to the rapid transition into aging population and the development of surgical instruments and technologies, the frequency of spinal fusion surgery has increased by 62% ever since the first spinal fusion survey has started in 2001. However, according to the statistics, the frequency of non-union after spinal fusion ranges from 5 to 30%, which has high possibility to cause severe pain or even neurological symptoms. In particular, the frequency of non-union increases in multi-segment fusion and highly related to the biologic and environmental factors of the patient. In order to prevent non-union after spinal fusion, bone grafting, commonly using autogenous bones collected from iliac crest, is performed simultaneously with spinal instrumentation. Accordingly, many studies have been conducted on substitutes that not only reduce the side effects of autogenous bone graft donor sites and but also increase the amount of bone graft. Few widely accepted examples are demineralized bone matrix, synthetic ceramics, and bone morphogenetic proteins, each of which has different biological characteristics. Until now, there have been many studies evaluating the union rate of demineralized bone matrix, synthetic ceramics, and bone morphogenetic proteins alone or in comparison between two groups; however, no other studies have yet compared the effects of the three substances at the same time. Therefore, in this study, we transplanted demineralized bone matrix(DBM), biphasic calcium phosphate(BCP), bone morphogenetic protein(BMP) with a small amount of autogenous bone in the intertransverse process of the rabbit lumbar spine simultaneously. After that, we tried to compare the union rate and characteristics of the transplant site macroscopically, radiologically, and histologically.
Jae-sung Ahn has completed his Ph.D. from Kyung Hee University, Korea. He is the head of orthopaedic surgery department of Chungnam National University, Korea